Don't just draw a block; classify it. Using the Map 3D toolset, you can attach Object Data to entities. This turns a simple block into a data-rich point (e.g., Valve Type: Gate, Status: Open). Once data is attached, you can perform Property Queries (Find all "Gate Valves") or Location Queries (Find all valves inside Zone A).
However, if you need raster analysis, network routing, or advanced geostatistics, stick with ArcGIS Pro or QGIS. Use AutoCAD to prepare the data, then export it. cad spatial analysis autocad